In 1972, Artashes Geghamyan joined the Communist Party of the Soviet Union. During 1976 – 78, he was elected and worked as the first secretary of Komsomol (Young Communists’ League) organisation of the Institute that comprised 19,000 people. During the same period of 1976 – 78, he worked as a head of the Students Department of Komsomol Headquarters. During 1979 – 86, he worked as an executive, head of department, supervisor, first deputy head of the department of the Council of the Communist Party of Armenia. During 1987 – 89, he was elected and worked as the first secretary of the Mashtotz District Council of the Communist Party.

In 1989 – 90, Artashes Geghamyan was elected and worked as a Mayor of Yerevan. In 1990, he quit the Communist Party. During 1991 – 95, Artashes Geghamyan worked as a Chief Executive of “Prometheus” stock exchange, and subsequently of the “21st Century” Ltd.

In 1995, Artashes Geghamyan was elected to the National Assembly (a.k.a. Parliament) of Armenia. In April 1997, Artashes Geghamyan founded “National Unity” NGO. In February 1998, the “National Unity” NGO at its extraordinary session proposed Artashes Geghamyan as a candidate for the Presidential Elections of 1998. Artashes Geghamyan is married and has two sons.